C. elegans CRISPR/Cas9 Service

Targeted changes in the genome offer the ability to address fundamentally important questions. Genome editing tools based on the CRISPR-Cas9 system are a breakthrough technology, which can precisely modify a genome in a relatively simple manner. 

The system is RNA-based bacterial defense mechanisms designed to recognize and eliminate foreign DNA from invading bacteriophage and plasmids. They consist of a Cas endonuclease that is directed to cleave a target sequence by a guide RNA (gRNA). Therefore, the system can be co-opted to cleave any target sequence of choice by modifying the sequence of the gRNA, which is encoded by a "CRISPR/array" in the bacterial genome. Learn more: CRISPR/Cas9 C. elegans Model